Natural Health News – Could high doses of resveratrol, long term, help stabilize declining in people with mild to moderate Alzheimer’s disease?
Resveratrol is a natural compound found in foods like red grapes, raspberries, black chocolate and some red wines. The recent study, however, uses a pure synthetic resveratrol (pharmaceutical grade) that is not yet available on the market. However, some positive results point the way to treatments based on the possibility that this natural substance for a disease that is becoming more common in our aging population.
The study involved 119 participants. The highest dose tested resveratrol was one gram orally twice a day -. Equivalent to the amount found in about 1,000 bottles of red wine What you need to know
“ Resveratrol is a natural antioxidant found in foods such as red grapes, raspberries, black chocolate and some red wines.
“ Studies show that activates proteins called sirtuins, the same proteins activated by caloric restriction, so it may be useful to help treat the disease related age such as Alzheimer’s.
“ Alzheimer placed in a high dose regimen of resveratrol pharmaceutical grade one year showed some signs that a biomarker of Alzheimer’s disease, pieces protein called amyloid-betea40, had stabilized -. although mineral research is necessary to understand the mechanism
The researchers then monitored the levels of several biomarkers, including amyloid beta40 (Abeta40) protein whose levels decrease as the disease progresses.
Keeping things stable
According to the findings, published in the journal neurology those who were treated with increasing doses of resveratrol for 12 months showed little or no change in the levels of amyloid beta40 (Abeta40) . On the contrary, those who received a placebo had a decrease in Abeta40 levels compared to their levels at the start of the study.
“A decrease in Abeta40 is seen as dementia worsens and Alzheimer’s disease progresses explains R. Scott Turner, MD, PhD, director of the Program Memory Disorders at Georgetown University Medical Center. He points out that it is impossible conclude a study that therapy with resveratrol is beneficial, he adds, “it seems that resveratrol was able to penetrate the blood-brain barrier, which is an important observation. Resveratrol was measured in the blood and cerebrospinal fluid. “
Researchers studied resveratrol because it activates proteins called sirtuins, the same proteins activated by caloric restriction. The biggest risk factor for developing Alzheimer’s disease is aging, and animal studies found that most age-related diseases – including Alzheimer’s -. Can be prevented or delayed by the long-term calorie restriction (consuming two thirds of the normal caloric intake)
Reduction of brain inflammation
Turner says the study also found that resveratrol was safe and well tolerated. The most common side effects experienced by participants were related gastrointestinal including nausea and diarrhea. In addition, patients taking resveratrol experienced weight loss, while placebo patients gained weight.
One of the results, in particular, was disconcerting, Turner notes. The researchers obtained magnetic resonance imaging of the brain of the participants before and after the study, and found that patients treated with resveratrol lost more brain volume than in the group treated with placebo.
“We’re not sure how to interpret this finding. A similar decrease in brain volume was found with some trials of anti-amyloid immunotherapy,” adds Turner. One thought is that treatments can reduce inflammation (swelling of the brain or) found with Alzheimer’s disease.
resveratrol and similar compounds are being tested in many age-related such as cancer, diabetes and neurodegenerative disorders disorders. However, this study, says Turner, is the largest, trial longest and highest doses of resveratrol in humans to date.